5 Critical Spravato Side Effects Patients Need to Know: Expert Guide to Treatment Success

For individuals battling treatment-resistant depression, Spravato (esketamine) offers a groundbreaking path to relief when traditional medications have failed. However, understanding potential side effects is crucial for patients considering this innovative therapy. At Spravato Treatment Centers of New Jersey, we believe informed patients achieve better outcomes. This comprehensive guide walks you through what to expect during Spravato treatment, empowering you to make confident healthcare decisions.

1. Temporary Dissociation: Understanding the Most Common Experience

Dissociation—feeling disconnected from your surroundings or yourself—occurs in approximately 41% of patients during treatment. This sensation typically begins shortly after administration and resolves within 1-2 hours. Many patients describe feeling “floaty” or experiencing altered perception.

The good news? This side effect typically diminishes with repeated treatments. Our clinical team at Spravato Treatment Centers of New Jersey carefully monitors each patient throughout their session, ensuring comfort and safety while these temporary sensations occur.

Important note: Due to dissociative effects, patients must remain at the treatment center for 2 hours of monitoring and cannot drive themselves home after receiving Spravato.

2. Blood Pressure Changes: What Heart Health Monitoring Looks Like

Approximately 17% of patients experience temporary increases in blood pressure—typically peaking around 40 minutes after administration and returning to normal within 2 hours. For most patients, these changes aren’t medically concerning but require careful monitoring.

Our protocols include baseline blood pressure readings before treatment and scheduled checks throughout your appointment. Patients with cardiovascular conditions undergo additional screening before beginning Spravato therapy.

3. Nausea and Dizziness: Managing Digestive and Balance Effects

About 28% of patients report nausea, while 23% experience dizziness during treatment sessions. These symptoms typically resolve quickly but can be uncomfortable in the moment.

Simple preparation strategies can significantly reduce these effects. Our team recommends:

Avoiding heavy meals 2 hours before treatment
Staying well-hydrated (but limiting fluids 30 minutes before administration)
Informing your provider immediately if nausea becomes severe

For those with persistent symptoms, our medical team can discuss anti-nausea medications that may help, as detailed in our comprehensive side effects management guide.

4. Sedation and Drowsiness: Post-Treatment Recovery Timeline

Approximately 23% of patients experience sedation, and many report feeling tired after their session. Most patients find this mild and manageable, but it reinforces why having a driver is essential.

Fatigue typically resolves within 24 hours after treatment. Planning your schedule accordingly—perhaps scheduling sessions when you can rest afterward—can make the experience more comfortable.

5. Anxiety and Emotional Responses: Navigating Psychological Effects

Some patients (about 13%) temporarily experience increased anxiety during treatment. This often subsides quickly but can be unsettling for unprepared patients.

Our clinical team creates a calming environment with reduced lighting, comfortable seating, and optional noise-canceling headphones. Many patients find that listening to relaxing music helps create a positive experience despite these temporary sensations.

Olivia’s Breakthrough: From Engineering Solutions to Finding Her Own

“As an engineer, I’m trained to solve problems—but when it came to my depression, nothing was working,” recalls Olivia, a 45-year-old patient at our Chatham location. After multiple failed medication trials over eight years, her psychiatrist recommended Spravato.

“During my first treatment, I experienced the dissociation they warned me about. It was strange but not frightening because the staff had prepared me well. I felt dizzy and a bit nauseated initially, but by my third session, those effects were minimal.”

Six weeks into treatment, Olivia noticed dramatic improvements. “For the first time in nearly a decade, I feel present in my own life. My concentration at work has returned, and I’ve reconnected with friends I’d withdrawn from.”

Olivia continues maintenance treatments at Spravato Treatment Centers of New Jersey and emphasizes the importance of understanding potential side effects. “Knowing what to expect made all the difference in sticking with treatment long enough to see results.”

Frequently Asked Questions About Spravato Side Effects

How long do Spravato side effects typically last?
Most acute side effects resolve within 1-2 hours after administration, which is why the mandatory monitoring period exists. By the time you’re cleared to leave with your designated driver, most effects have substantially diminished.

Do side effects improve with continued treatment?
Yes, many patients report that side effects like dissociation and nausea become less pronounced with subsequent treatments. Your body often adapts to the medication over time.

Will insurance cover Spravato despite these side effects?
Most insurance providers recognize Spravato as a medically necessary treatment for TRD when properly prescribed. The side effect profile doesn’t typically impact coverage, though specific plans vary. Visit our insurance and cost information page for details about verification and assistance programs.

Conclusion: Balancing Side Effects Against Potential Benefits

While Spravato side effects require consideration, they must be weighed against the potential for significant symptom relief in treatment-resistant depression. With proper medical supervision—like that provided by our specialized team—these effects can be managed effectively, allowing patients to experience the full therapeutic benefit.

Understanding what to expect creates confidence. Most side effects are temporary and manageable, especially when you’re prepared. Our detailed Spravato FAQ section addresses additional concerns you might have about the treatment process.

If you’re considering Spravato for treatment-resistant depression, schedule a consultation to discuss your specific health situation and develop a personalized treatment plan that addresses your concerns about potential side effects.

Author’s Bio

Dr. David Boguslavsky, MD, is a highly experienced family physician and medical acupuncturist with over two decades of clinical practice, who has emerged as a leader in mental health treatment, particularly in the field of depression. A graduate of Robert Wood Johnson Medical School, Dr. Boguslavsky is board-certified in both Family Medicine and Medical Acupuncture, showcasing his diverse medical expertise. His extensive experience spans a wide range of medical care, from acute illnesses to chronic condition management, with a particular focus on preventative care and pain treatment. Notably, Dr. Boguslavsky has pioneered innovative approaches to depression treatment, having administered over 10,000 Spravato treatments, establishing himself as one of the foremost experts in this cutting-edge therapy. His unique blend of traditional Western medicine, Eastern acupuncture techniques, and advanced psychiatric treatments allows him to offer comprehensive, personalized care to his patients at PremierMD and Spravato Treatment Centers of NJ. Fluent in English and Russian, Dr. Boguslavsky brings a multifaceted approach to healthcare, combining the latest medical technologies with time-honored principles of doctor-patient relationships to address both physical and mental health needs.

5 Critical Spravato Side Effects Every Patient Should Know Before Treatment

Published: February 24, 2025

Are you or a loved one considering Spravato for treatment-resistant depression? Understanding potential side effects before starting this breakthrough nasal spray therapy can dramatically improve your treatment experience and outcomes. At Spravato Treatment Centers of New Jersey, we believe informed patients achieve better results. This comprehensive guide reveals everything you need to know about managing Spravato side effects—information that could make the difference between treatment success and unnecessary discomfort.

What Exactly Is Spravato and How Does It Work?

Spravato (esketamine) works differently than traditional antidepressants by targeting the NMDA receptors in your brain. This FDA-approved medication offers hope for the 30% of depression patients who don’t respond to conventional treatments. Before discussing side effects, it’s important to understand that Spravato is always administered under medical supervision at certified treatment centers like ours in Chatham, New Jersey.

The 5 Most Common Spravato Side Effects You May Experience

Based on clinical studies and our extensive patient experience at Spravato Treatment Centers of New Jersey, these are the side effects most patients should be prepared for:

Dissociation: Approximately 41% of patients experience feeling disconnected from reality or altered perceptions. This typically resolves within 1-2 hours after treatment.
Dizziness and Nausea: Nearly 29% of patients report feeling dizzy or nauseated during or shortly after administration. Having a light meal before treatment can help minimize these effects.
Blood Pressure Changes: About 17% of patients experience temporary increases in blood pressure, which is why monitoring is required during each treatment session.
Sedation and Drowsiness: Around 23% of patients feel extremely relaxed or sleepy, which is why you’ll need someone to drive you home after treatment.
Anxiety or Agitation: Some patients (13%) report temporary feelings of anxiety during the treatment experience.

Olivia’s Journey: From Treatment-Resistant Depression to Renewal

Olivia, a 45-year-old engineer from northern New Jersey, had battled treatment-resistant depression for over a decade. “I tried six different antidepressants and years of therapy with minimal improvement,” she recalls.

“I was skeptical about Spravato at first, especially after reading about the side effects online. But the team at Spravato Treatment Centers of New Jersey walked me through exactly what to expect. Yes, I experienced some dissociation during my first few treatments—it felt like I was floating outside myself—but the medical staff made me feel safe throughout the experience. By my third treatment, I noticed a significant improvement in my depression symptoms for the first time in years.”

Today, Olivia continues maintenance Spravato treatments and reports an 80% reduction in her depression symptoms. “The temporary side effects were a small price to pay for getting my life back,” she says.

How Our Medical Team Manages Side Effects

At Spravato Treatment Centers of New Jersey, our experienced medical team led by our Medical Director has developed protocols specifically designed to minimize discomfort during treatment:

Pre-treatment preparation guidance to reduce nausea
Comfortable, private treatment rooms with calming environments
Continuous monitoring by specialized healthcare professionals
Post-treatment recovery period with personalized support
Follow-up care to address any lingering side effects

Will Insurance Cover Spravato Despite Its Side Effects?

Many patients worry that insurance companies might deny coverage due to potential side effects. The good news is that most major insurance providers now recognize Spravato’s effectiveness for treatment-resistant depression. Visit our cost and insurance page to learn about coverage options and our assistance programs that make treatment accessible regardless of your financial situation.

Important Safety Information

Spravato carries a boxed warning for sedation, dissociation, and potential misuse. That’s why treatment can only be administered at certified facilities with proper monitoring. Our medical team conducts thorough evaluations to ensure Spravato is appropriate for each patient’s specific situation.

Frequently Asked Questions About Spravato Side Effects

Our patients often have specific concerns about side effects before starting treatment. Here are answers to the most common questions we receive at our Chatham clinic:

How long do the dissociative effects typically last?
Most patients find that dissociation resolves within 1-2 hours after treatment. By the time you’re cleared to go home (approximately 2 hours post-treatment), these effects have typically subsided significantly.

Can I drive after receiving Spravato?
No. Due to the potential for drowsiness and dissociation, you must arrange for someone to drive you home after each treatment session. You should not operate machinery or make important decisions until the following day.

Do side effects diminish with continued treatment?
Many patients report that side effects like dissociation and dizziness become less intense as they progress through their treatment course, though individual experiences vary.

Taking the Next Step in Your Treatment Journey

Understanding potential side effects is crucial when considering Spravato treatment, but it’s equally important to weigh these temporary discomforts against the potential for significant relief from treatment-resistant depression. At Spravato Treatment Centers of New Jersey, we’re committed to providing comprehensive support throughout your treatment journey.

Our experienced team has helped hundreds of patients like Olivia navigate Spravato therapy successfully, minimizing side effects while maximizing benefits. Ready to learn if Spravato might be right for you? Contact our Chatham office today to schedule a consultation and take the first step toward renewed mental wellness.

Author’s Bio

Notably, Dr. Boguslavsky has pioneered innovative approaches to depression treatment, having administered over 10,000 Spravato treatments, establishing himself as one of the foremost experts in this cutting-edge therapy. His unique blend of traditional Western medicine, Eastern acupuncture techniques, and advanced psychiatric treatments allows him to offer comprehensive, personalized care to his patients at PremierMD and Spravato Treatment Centers of NJ. Fluent in English and Russian, Dr. Boguslavsky brings a multifaceted approach to healthcare, combining the latest medical technologies with time-honored principles of doctor-patient relationships to address both physical and mental health needs.